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Year : 2021  |  Volume : 35  |  Issue : 4  |  Page : 197-202

Nonalcoholic fatty liver disease among long-term hospitalized patients with schizophrenia in a public psychiatric hospital

1 Department of Family Medicine, Yuli Hospital, Ministry of Welfare and Health, Yuli Township, Hualien County, Taiwan
2 Department of Psychiatry, Yuli Hospital, Ministry of Welfare and Health, Yuli Township, Hualien County; Department of Psychiatry, Taipei Veterans General Hospital, Taoyuan Branch, Taoyuan City, Taiwan
3 Department of Psychiatry, Yuli Hospital, Ministry of Welfare and Health, Yuli Township, Hualien County, Taiwan

Correspondence Address:
M.D., Ph.D Tso- Jen Wang
448 Chung-Hua Road, Yuli Township, Hualien County 981
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/TPSY.TPSY_38_21

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Objectives: Nonalcoholic fatty liver disease (NAFLD) is a notable chronic liver disease due to metabolic syndrome, which has yet to be explored in long-term hospitalized patients with schizophrenia. In this study, we intended to study the prevalence of NAFLD and related risk factors for patients with schizophrenia who were long-term hospitalized. Methods: All of 182 patients with schizophrenia were recruited from a public psychiatric hospital in Taiwan. Abdomen ultrasonography was carried out for all patients. In addition to age and sex, covariates including medical diagnoses (e.g., hypertension, hypertriglyceridemia, hypercholesterolemia, and diabetes), obesity, one-year cumulative dose of antipsychotics before the entry of this study, and abnormal liver function were included in the logistic regression model. Results: The mean age ± standard deviation (SD) was 50.3 ± 9.2 years. The mean duration ± SD of hospitalization was 8.7 ± 5.0 years. Males accounted for 60.4% (110/182). The percentage of NAFLD was 70.8% (129/182). In multivariate logistic regression, patients' odd ratios (OR) (95% confidence interval [CI]) for a diagnosis of hypertriglyceridemia were 4.3 (1.11–16.7, p < 0.05) and for a finding of obesity 15.8 (3.82–65.6, p < 0.01), were significantly to have NAFLD. But patients with chronic hepatitis B were not significant to have NAFLD (OR [95% CI] = 0.17 [0.05–0.6]). Conclusion: The prevalence of NAFLD was high in patients with long-term hospitalized patients with schizophrenia in this study. We suggest that patients with schizophrenia and with long-term hospitalization need to receive timely, comprehensive, and prompt assessments for the presence of NAFLD as well as that intervention for their NAFLD is mandatory for maintaining well-being and quality of life in them.

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